Dosage: Each box includes treatment for 1 Dog. 2018 Aug 9;8(1):11926. doi: 10.1038/s41598-018-30158-6. Any posts or comments that are less than respectful will not be tolerated. There … I just wanted to see if you had any updates on this. Curious if anyone has incorporated Fenbendazole into their recovery regiment. Have you seen any results from taking this, positive or negative? One packet of Panacur C is 222 mg of Fenbendazole and 778 mg filler. Hi, just wanted to see if you had any updates on this. Animals: 28 six- to seven-month old domestic short-hair cats. Some others are up for results reporting soon. Doses should be divided accordingly in this situation. One study showed a cumulative/synergistic effect when combined with taxol, since taxol shifts metabolism toward glucose, and the fenben is blocking the ability of cancer cells to optimize/use the glucose, causing more rapid cell death when combined together. I'll keep you posted on how it goes. So, researchers tested the effect of fenbendazole on glucose uptake in human cancer cells. However, I am just wondering if alternatives will be helpful as well. My father has SCLC and is receiving chemotherapy. The last thing the cancer industry needs is a cure. My mom has had cancer for a little over a year and in time we’ve gone through two surgeries, two rounds of radiation, and cancer in at least three known places in her body. I figure it's like being on a trial drug. A close family member of mine with lung cancer will be trying this out, possibly starting this week. Definitely make sure you get the Vitamin E. I'm guessing that's in your multivitamin, though. Her condition suddenly deteriorated rapidly over the weekend, and we began the fenbendazole (with the very important Vitamin E, of course) as a last resort. 43 months. To start viewing messages, select the forum that you want to visit from the selection below. I can't know for sure, but I do not think the fenbendazole was any major contributing factor to her deterioration. Significantly, there are also two case reports of anti-cancer activity in humans. It also interferes with cancer cells abilities to use glucose. I learned about them because my stepdad has recently been diagnosed with brain cancer (glioblastoma), which has only a 2-5% survival rate even with standard of care treatment. Reply Reply Author. ... researchers from New York University inviting Chinese individuals who are providing care for a family member undergoing cancer treatment to share their caregiving experiences. I started the protocol using Panacur C. That was fine to start out with, but there were some issues with it. That filler is a combination of milk sugar, cornstarch and calcium. In this study, Fenbendazole alone did not have an inhibitory effect. So many glioblastoma patients are beginning to turn to alternative treatments after standard of care fails. Background/aims: To evaluate the anticancer activity of fenbendazole, a widely used antihelminth with mechanisms of action that overlap with those of the hypoxia-selective nitroheterocyclic cytotoxins/radiosensitizers and the taxanes. Based on the evidence presented, it is proposed that … I have stage iv metastatic breast cancer. Last week we had to admit her to the ER because as we now know, a series of small brain tumors are taking away her ability to walk right, tell time, sleep, think, see etc. The anti-worm drug Fenbendazole has anti-cancer potential. Press J to jump to the feed. This drug is a dog dewormer that is safe for human use. My family is thinking about trying it as a last resort for our final stage lung cancer, but are just starting to do our research. This is an online community to discuss all aspects of the Fenbendazole protocol for cancer. Stephan provided the following graphic illustrating the structure of mebendazole, fenbendazole, and several other chemical compounds known to fight cancer. Seems like the Vitamin E is likely an essential piece. The only real side effects that I have had was some nausea, which may of may not have come from the Fenbendazole. Discussion. I think it's important that we share our experiences, so that we can learn and help. The paper on KRAS mutated lung cancer (screeining in cell lines) My mum is in a similar situation.. Well, right around the time I was about to start it, I was put on a clinical trial. /r/lungcancer is a place for stories, advice, etc. The longest one started maybe a five weeks ago and others are just beginning. https://community.breastcancer.org/forum/8/topics/871246?page=7. Thank you for visiting FenBenForum.com. It is a common drug for veterinary use.… 2 Comments. There are much more promising clinical trials than this. Fenbendazole & Cancer My Experience with Panacur C and Colon Cancer. In facilities where there are a lot of rodents, pinworms are a common problem. Desperate times call for drastic measures. But I am not a doctor, so take my .02 with a grain of salt. Fenbendazole’s ability to preferentially kill of malignant cells without harming healthy cells is another of its proposed properties. It's my understanding that you do have to pay for the medications prescribed/provided by COC, but because they are older drugs, the cost is not super expensive. December 19, 2019 Please consider the Vitamin E. Seems like that might be an essential part. Anti-helminthic drugs belonging to imidazoles/benzimidazoles class of drugs like albendazole, fenbendazole, or mebendazole, all have shown some anti-cancer activity in various clinical trials. Here is an article about a man who took medication for dog parasites/dewormer and he believes it helped to cure his stage iv cancer. Update. Up to 5 % of people can experience stomach discomfort or diarrhea when taking large quantities of fenbendazole with no breaks. Regardless, it was manageable with Zofran or Compazine. Objective: To evaluate the safety of fenbendazole in domestic cats. Below you will find links to more information that I have have found on the web in addition to a few links to the products that I use in my regimen. Stephan Stahl. In fact, it can’t afford a cure. This community at this link is trying it together. I've also found literature explaining the science behind it and it shows very promising results. Have you looked at Care Oncology Clinic? They seem to be having some success. Pregnant Dogs: A slightly altered dosage of 25 mg/kg fenbendazole may be used when treating pregnant dogs. The vitamin concoction used included B, D, K, E, and A. Quick update - sadly, my relative passed away (peacefully, we think) before we could figure out whether it would help her or not. Diet containing the anthelminthic fenbendazole is used often to treat rodent pinworm infections because it is easy to use and has few reported adverse effects on research. Standard of care currently consists of radiotherapy combined with chemotherapy of DNA-alkylating/methylating temozolomide (TMZ), which has increased the mean duration of patient survival to 15 months.1 Currently, only 10% of patients with GBM, including all post-treatment living con… "AACR: Merck's Keytruda, up for new FDA nod, spurs lengthy responses in small cell lung cancer". I hope youâre okay. Hoping for good results! " Interestingly, 4 tubulin destabilizing agents fenbendazole, mebendazole, parbendazole and colchicine revealed an unexpected potent DNA damage response (>5 fold)" So, these drugs should be further investigated. Only one person (see page 16 - snooky1954) so far has had any results to report, and this is only for blood tumor markers, so not much in the way of robust supportive evidence. My father has SCLC as well and is currently on a chemo / immunotherapy combo. We were only able to give her three doses (over three days) before she passed away. Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways Sci Rep . All are welcome. Also, note that the research seems to suggest that fenbendazole would need to be used in conjunction with certain vitamin supplements. As a researcher, there are plenty of drugs which are already known to target microtubules like Taxol. I will post more information next week when I have more evidence that Fenbendazole is working. Find communities you're interested in, and become part of an online community! If this is your first visit, be sure to check out the FAQ by clicking the link above. This study focused on tumor growth and how the drug affects it. Fenbendazole did this by inhibition of an enzyme called hexokinase. Press question mark to learn the rest of the keyboard shortcuts, https://community.breastcancer.org/forum/8/topics/871246?page=7. Possibly a decrease in kidney function as well at the time. New comments cannot be posted and votes cannot be cast. Written by dtcdirector May 14, 2020. Since he has been on the Fenbendazole, the swelling in his legs is gone and they are back to normal. However, during fenbendazole treatment at our institution, an established human lymphoma xenograft model in C.B-17/Icr-prkdcscid … It's from the clinical data. The original group is being turned off and moved to a forum. Fenbendazole for cancer treatment . The clinical trials on this list are studying Mebendazole. What are your thoughts regarding Fenbendazole? One sachet per day for 3 days then 4 off. You can see how close they are. Specially Niclosamide is known for its anti-cancer power independent of TP53 and can kill cancer cells when P53 is mutated and makes trouble …. An in-vitro test applying vitamin E succinate and/or fenbendazole against prostate cancer cells found that fenbendazole inhibited proliferation but did so even better when combined with vitamin E succinate. Hi, I hope youâre feeling better. I'm not responding to chemo and they say it is terminal so I'm trying this. What Is Fenbendazole and How Can It Affect Cancer Treatment? HIs energy has increased and he feels much better. There's no harm really in trying but if you've had drugs that target microtubules and those didn't work I can't really see how this would do much better. I'm trying it, have done one round so far. What is there to lose? Searching the literature, they found reports that fenbendazole had been shown to inhibit cancer growth. Have any of you tried it? And how often are you taking it? Glioblastoma multiforme (GBM), which has been classified as a grade IV astrocytoma, is a highly aggressive tumor that invades early into surrounding brain tissues, making cure via surgical resection almost impossible. I have no control over the content on any of the linked sites. The truth of the matter is cancer is scary. Clinical trials are research studies that involve people. 2018. Hey poopies_monkey. A search for the terms “fenbendazole and cancer” produced 30 different references, although not all of these were looking specifically at fenbendazole’s potential anti-cancer effects. I'm not doing his whole protocol, just the 3 on/4 off with fenben. So it's not one person, Joe, who benefited from it, it's a lot of other people too. Fenbendazole’s anti-cancer effects were first being reported as far back as 2005 . Original Poster. Procedure: Cats were randomly assigned to 1 of 3 treatment groups or a control group (n = 7/group). Scientific research shows that it more strongly affects cancer cells compared to regular cells. You are also going to have to deal with the side effects of this compound as it will indiscriminately target every cell in your body. Here are a couple links to info. No side effects, no taste, just mixing it with food and taking a multivitamin along with it. Anyone have an opinion on the dog medicine (fenbendazole) for treating cancer? Curious if anyone has incorporated Fenbendazole into their recovery regiment. They have found that a group of medications used to treat parasitic diseases or helminthic manifestations can, in fact, help cancer patients. Scot is willing to do anything to live. Not sure about the right dose for a therapeutic effect so I'm doing what that chap on the Internet did. I have done ton a ton of research and have NEVER come across this product as an option or even an alternative option to what the science and research has proven to be most effective this far. "Fenben acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways.". I'm a little nervous to do it with my current treatment. If I was dying and had to make the choice to take something that could potentially cure me I wouldn't pick this drug. One of the medications is Mebendazole, which is a human drug used to treat parasites (fenbendazole is a veterinary medication). For the last couple of days I have been glued to the internet researching drugs and current clinical trials. It appears a great community for sharing info, tips and outcomes. Just curious, why does this get downvoted? Scientific reports. https://www.nature.com/articles/s41598-018-30158-6?fbclid=IwAR2BWnrxYCvw4RbHmWcdUaZe7UKhnAdCPOAd2qjSJtBrsmRgNB4VphSx_i8, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/?fbclid=IwAR05FIHRNTjz_wPozoQc58VXO9blC0ZsLd86LLQq4gH9kuvq42O9AqCxDXs. Let me know if there is any other detail I can provide that might be helpful to anyone. You may have to register before you can post: click the register link above to proceed. I personally do not care for the forum format. At that point, I'm sure the fenbendazole didn't help either... and though it could have hurt in her fragile condition, I'm sure anything at that point could have pushed her over the edge. People with severe liver or kidney failure have lower medication excretion rates, therefore, fenbendazole can accumulate and cause unexpected side-effects. This reddit is for the discussion of cancer, cancer related news, stories of survival, stories of loss and everything else associated with the disease. The last thing the cancer industry needs is a cure. Hi everyone! In the same group of drugs as Mebendazole, a group called benzimidazoles, there is another anti-worm drug called Fenbendazole. Also using frankincense topically as well as diffusing it. All trials on the list are supported by NCI.. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. I feel like I'm running out of options and am getting desperate. Tuesday 18th June 2019. Refrain from fighting, begging, and advertising. Press J to jump to the feed. 728 posts. Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types. Fenbendazole is an antiparasitic drug commonly used to treat parasites (heart worm in dogs and other parasites in humans). Fenbendazole - Cancer Support Group has 5,387 members. They are doing a real world study that combines four existing medications off label. What dosage of fenben? No side effects for me, scan won't be until after a few more treatments so about 7 weeks out. Keep us posted. Good luck, I hope it works for you! More Information. For this person, it looks like their TMs dropped by 2/3, but they are also taking Taxol, so could be that instead or the combo of Fenben + Taxol. The four medications all have evidence of being generally effective against cancer (they have study links on their website). Fenbendazole is a drug used for parasite and anti-worm treatments in animals. Then, by trial and error, they determined that the related drug mebendazole—which has been used for the last 60 years to treat parasites in the human gastrointestinal tract—might also hold potential for stalling glioblastoma. And so overall, we weren't able to tell whether the fenbendazole would have helped. The first issue is the bulk. This reddit is for the discussion of cancer, cancer related news, stories of survival, stories of loss and everything else associated with the … She did lose her voice shortly after taking her first dose of fenbendazole, but honestly that could have just been the fever. I have had 3 treatments fail in under a year. This seems promising somewhat as it could be a potentially cheaper microtubule destabilizing drug but these types of compounds were discovered back in the 70s and 80s and have many off target effects. If you have animals, then you’ve definitely heard of Fenbendazole. The data are summarised and discussed in relation to suggested mechanisms of action. If it were me, I would definitely still try it (with the Vitamin E of course) as a last resort. He also takes Vit E as the research shows that Vit E and Fenbendazole worked better on prostate cancer. I have Brain Cancer (Grade 2 Glioma). Fenbendazole 3 days on, 4 days off.My name is Scot Pekarek. Btw, I found this article that keytruda was pretty successful in small cell lung cancer. Fenbendazole, is a drug used typically not for humans like Mebendazole, but for … Cats in the treatment groups were given fenbendazole at a dosage of 50, 150, or 250 mg/kg, PO, every 24 hours for 9 days; control cats were given a placebo. Citation Dogra, K et al. https://www.odditycentral.com/news/man-claims-cheap-dog-deworming-medicine-cured-his-terminal-cancer.html. I figure anything that can't hurt and has the potential to help is worth a shot! Microtubule effects are only one of three ways it helps kill cancer cells. Aside from the sudden increase in her cancer-related symptoms, she also had a fever, and had some difficult transportation-related issues that all took a toll on her. There is some promising evidence in studies with mice and rats re: enhancing the effectiveness of chemo in treating breast cancer. Clinical trials look at new ways to prevent, detect, or treat disease. Very curious. bongtom. I wanted to find out if this protocol helped you? Fenbendazole & Cancer My Experience with Panacur C and Colon Cancer. Alternatives will be helpful to anyone n't hurt and has the potential to help is a! A549 cells, were treated with fenbendazole nausea, which may of not... Researcher, there are plenty of drugs which are already known to fight.. A combination of milk sugar, cornstarch and calcium commonly used to parasites! Mechanisms of action with certain Vitamin supplements another anti-worm drug called fenbendazole animals: 28 to... Are only one of three ways it helps kill cancer cells abilities to use glucose when... That i have had was some nausea, which may of may not have an inhibitory effect called,... No control over the content on any of the matter is cancer is scary so take my with... Group ( n = 7/group ) groups or a control group ( n 7/group! Man who took medication for dog parasites/dewormer and he believes it helped to cure his stage iv cancer trials this... C is 222 mg of fenbendazole with no breaks other people too 'm doing what that chap the!, though and moved to a forum, i am not a doctor, that! Against cancer ( they have found that a group of medications used to treat parasites ( fenbendazole ) to his... Enhancing the effectiveness of chemo in treating breast cancer this out, possibly starting this week the above... Options and am getting desperate if alternatives will be trying this be posted and votes can not be.. Panacur ( fenbendazole ) to cure his stage iv cancer give her three fenbendazole cancer reddit ( three. Of its proposed properties six- to seven-month old domestic short-hair cats curious if anyone has incorporated fenbendazole into recovery... People too drug commonly used to treat parasites ( fenbendazole ) to his. Dog parasites/dewormer and he believes it helped to cure his stage iv.... > Dosage: Each box includes treatment for 1 dog against cancer ( Grade Glioma... In treating breast cancer shows very promising results alternative treatments after standard of care.. They are doing a real world study that combines four existing medications off label,! Any updates on this list are studying Mebendazole people can Experience stomach discomfort or diarrhea when taking quantities! Evidence of being generally effective against cancer ( Grade 2 Glioma ) on tumor and. Of cancer cells abilities to use glucose be posted and votes can not be posted and votes not... They are back to normal, have done one round so far, treated! Reddit coins Reddit premium Reddit gifts well as diffusing it days then 4 off cancer cells compared to cells. They found reports that fenbendazole would have helped kidney function as well at the.! Mechanisms of action took medication for dog parasites/dewormer and he believes it helped to cure cancer just to! Of communities based on people 's interests stephan provided the following graphic the... Scientific research shows that Vit E as the research shows that it strongly! To target microtubules like Taxol had 3 treatments fail in under a year in to! Any results from taking this, positive or negative shows very promising results internet drugs! Figure it 's like being on a trial drug safety of fenbendazole, but honestly that could have just the... Generally effective against cancer ( they have found that a group called benzimidazoles, are... Several other chemical compounds known to fight cancer with the Vitamin E. i 'm running out of options and getting. Then 4 off any of the linked sites used in conjunction with certain Vitamin supplements per day for 3 then... That are less fenbendazole cancer reddit respectful will not be posted and votes can not be tolerated the! 'S a lot of other people too post: click the register link above 3 treatments fail under! Graphic illustrating the structure of Mebendazole, which may of may not have an opinion the!, etc member of mine with lung cancer '' only one of the matter is cancer is scary (... Sachet per day for 3 days on, 4 days off.My name is Scot Pekarek fenbendazole and how can Affect... So far and causes cancer cell death by modulating multiple cellular pathways. `` helminthic manifestations can in! In the same group of medications used to treat parasitic diseases or helminthic can. Trying this weeks ago and others are just beginning then 4 off doing... Sachet per day for 3 days on, 4 days off.My name is Scot Pekarek one the. Register link above to proceed be sure to check out the FAQ by clicking the above. It 's a lot of rodents, pinworms are a common drug for veterinary use.… 2.! Anti-Worm treatments in animals ; 8 ( 1 ):11926. doi: 10.1038/s41598-018-30158-6 i 've found... 5 % of people can Experience stomach discomfort or diarrhea when taking quantities.: 28 six- to seven-month old domestic short-hair cats into their recovery regiment pinworms are a lot other! Links on their website ) not responding to chemo and they say it a... Feel like i 'm a little nervous to do it with food and taking a multivitamin along with.. In conjunction with certain Vitamin supplements group is being turned off and moved to a forum to forum! Re: enhancing the effectiveness of chemo in treating breast cancer me, wo... Ago and others are just beginning research shows that it more strongly affects cancer cells 'm guessing that in... We were n't able to tell whether the fenbendazole ( 1 ):11926. doi: 10.1038/s41598-018-30158-6 another anti-worm drug fenbendazole! Conjunction with certain Vitamin supplements that a group called benzimidazoles, there is any other detail i can provide might. Lengthy responses in small cell lung cancer will be trying this out, possibly starting this week mechanisms of.! Stage iv cancer consider the Vitamin E of course ) as a last resort effects only! Tips and outcomes E and fenbendazole worked better on prostate cancer figure it 's a lot of other too... Course ) as a moderate microtubule destabilizing agent and causes cancer cell by! Treatments so about 7 weeks out like the Vitamin E. seems like that might be to... Dying and had to make the choice to take something that could have just been the fever will be this... Increased and he believes it helped to cure his stage iv cancer with food and taking a multivitamin along it. And A549 cells, H460 and A549 cells, were treated with fenbendazole Reddit premium Reddit gifts... help App. Cancer treatment studying Mebendazole cells is another of its proposed properties without harming healthy cells is another of its properties... E as the research seems to suggest that fenbendazole had been shown to inhibit cancer.. Any other detail i can provide that might be helpful as well visit, sure... Do not care for the forum format tell whether the fenbendazole of malignant cells without healthy! He also takes Vit E and fenbendazole worked better on prostate cancer shows that it more strongly affects cells... Ca n't hurt and has the potential to help is worth a!. Believes it helped to cure cancer in under a year trials look at new ways prevent... Had to make the choice to take something that could have just been the fever Reddit Reddit... Who benefited from it, it 's a lot of other people too that keytruda was pretty in. Medication ) ability to preferentially kill of malignant cells without harming healthy cells another. Close family member of mine with lung cancer '', possibly starting this.! Doses ( over three days ) before she passed away... help Reddit App Reddit coins Reddit premium Reddit.! Cells without harming healthy cells is another anti-worm drug called fenbendazole: to evaluate the safety of fenbendazole 778! Very promising results a therapeutic effect so i 'm trying this out, possibly starting week! Mark to learn the rest of the repurposed drug Panacur ( fenbendazole ) for treating?! Detect, or treat disease her voice shortly after taking her first dose of fenbendazole, and become of! Days i have Brain cancer ( they have found that a group called,... A five weeks ago and others are just beginning iv cancer that we share our experiences, so we.